Childhood Asthma Prevention Study (CAPS)

Current CAR investigators involved: CIs Marks and Leeder

The original aim of this study was to test the effectiveness of house dust mite avoidance and dietary fatty acid modification, implemented for the first five years of life, as interventions to prevent the onset of asthma in children with a family history of asthma.

This started as an RCT of interventions for the prevention of asthma that was implemented for the first five years of life in a cohort with a positive family history of asthma. The cohort has now been closely followed, with measures of indoor environmental exposures and careful measures of respiratory, cardiovascular and metabolic outcomes, to age 11.5 years. Further follow-up at age 14 is about to commence. Of 616 subjects initially randomised, 450 were followed-up at age 8 years.

The data will be used to examine the effect of life-time exposure to ambient and traffic-related air pollution on respiratory, cardiovascular and metabolic outcomes. DNA from the subjects with asthma has been contributed to the Australian Asthma Genetics Consortium GWAS analysis. This study is a highly innovative community-based randomised controlled trial of preventive interventions. The richness of the data on outcomes and potential confounders makes it very valuable for air pollution studies.